Shannen Doherty - "Beverly Hills, 90210" (1990-1994): Departed due to clashes with cast and crew.
Charlie Sheen - "Two and a Half Men" (2003-2011): Controversial personal issues led to his dismissal from the show.
Chevy Chase - "Community" (2009-2014): Left amidst creative disagreements and a difficult working relationship.
Columbus Short - "Scandal" (2012-2014): Departed due to personal issues and legal troubles.
Katherine Heigl - "Grey's Anatomy" (2005-2010): Reported tensions with producers and a desire to focus on films.
Isaiah Washington - "Grey's Anatomy" (2005-2007): Fired after using a homophobic slur, resulting in public backlash.
Thomas Gibson - "Criminal Minds" (2005-2016): Fired after an on-set altercation with a producer.
Nicollette Sheridan - "Desperate Housewives" (2004-2009): Departed amid conflicts with the show's creator and mistreatment allegations.
Robert Knepper - "Heroes" (2006-2010): Negative reception led to his character being written out.
Lisa Bonet - "The Cosby Show" (1984-1991): Left due to creative differences and conflicts with Bill Cosby.