In the movie that brought Brad Pitt and Angelina Jolie together, their chemistry destroyed Pitt's marriage to Jennifer Aniston, resulting in their divorce and the beginning of "Brangelina," who later separated in 2016.
Tom Cruise's on-set romance with Nicole Kidman during the filming of 'Days of Thunder' (1990) ended his marriage to Mimi Rogers, leading to a quick divorce and a later marriage to Kidman, which ended in 2001.
Meg Ryan reportedly met Russell Crowe on the set of 'Proof of Life' while still married to Dennis Quaid, and their chemistry led to an affair, which didn't last but ultimately ended Ryan's marriage to Quaid in 2001.
Jennifer Garner and Ben Affleck's on-set chemistry during the filming of 'Daredevil' (2003) led to the end of Garner's marriage to Foley and Affleck's engagement to J. Lo, and ultimately, to their marriage in 2005, which ended in divorce in 2018.
During the filming of 'The Outlaw Josey Wales' (1976), Clint Eastwood fell in love with co-star Sondra Locke, leading to the end of his marriage to Maggie Johnson, while Locke stayed married until her death in 2018.
An affair between Kenneth Branagh and his co-star Helena Bonham Carter led to the divorce between Branagh and his then-wife Emma Thompson.
The TV movie 'Mind Over Murder' led to the end of two marriages, as Tori Spelling and Dean McDermott had an affair while married to other people, but they are still together today.